Article
Evaluating mitochondrial DNA in cancer occurrence and development.
Annals of the New York Academy of Sciences - 1 Jul 2010
Shen Lijun, Fang Hezhi, Chen Tao, He Jing, Zhang Mei, Wei Xiaosong, Xin Yijuan, Jiang Yulin, Ding Zhinan, Ji Jingzhang, Lu Jianxin, Bai Yidong
Abstract excerpt
Abnormal mitochondria have long been hypothesized to be involved in tumorigenesis. Mitochondrial DNA (mtDNA) mutations have been found in various cancer cells, yet their role in tumorigenesis remains largely unknown. Our long-term goal is to understand the role of mtDNA polymorphism and mtDNA mutations in tumorigenesis. We focused on the role of the mtDNA haplogroup; a 4,977 bp common mtDNA deletion; mtDNA...
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