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Article

Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.

Proceedings of the National Academy of Sciences of the United States of America - 8 Feb 2005

Sonoda Junichiro, Chong Ling Wa, Downes Michael, Barish Grant D, Coulter Sally, Liddle Christopher, Lee Chih-Hao, Evans Ronald M

Abstract excerpt

Efficient detoxification and clearance of cholesterol metabolites such as oxysterols, bile alcohols, and bile acids are critical for survival because they can promote liver and cardiovascular disease. We report here that loss of the nuclear xenobiotic receptor PXR (pregnane X receptor), a regulator of enterohepatic drug metabolism and clearance, results in an unexpected acute lethality associated with signs of...

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Share to Bile Acids and Salts
Share to Cholesterol, Dietary

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15671183
DOI: 10.1073/pnas.0409481102
PMCID: PMC548561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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