Back to search

Article

PXR-mediated metabolism during pregnancy and cholestasis

2009-01-01

Abstract excerpt

Nuclear receptors, including the pregnane x receptor (PXR) and the farnesoid x receptor (FXR), regulate the expression of genes that maintain bile acid (BA) homeostasis. Intrahepatic cholestasis of pregnancy (ICP) is a common gestational liver disease and BAs are implicated in its pathogenesis. Rodents exhibit maternal liver growth in order to meet the metabolic demands of pregnancy. This process is found to prece...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1d2f1b05-1a30-5fa6-b79b-a95b8dfda7cd
DOI
10.25560/4431
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PXR-mediated metabolism during pregnancy and cholestasisDOI 10.25560/4431
The pathophysiology of intrahepatic cholestasis of pregnancy.Semantic proximity
Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and DiseaseSemantic proximity
The molecular genetics of intrahepatic cholestasis of pregnancySemantic proximity
Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype.Semantic proximity
PXR: A Xenobiotic Receptor of Diverse Function Implicated in PharmacogeneticsSemantic proximity
Mechanisms and Therapeutic Advances of PXR in Metabolic Diseases and CancerSemantic proximity
Molecular pathogenesis of intrahepatic cholestasis of pregnancy.Semantic proximity
Cholestasis and cholestatic syndromes.Semantic proximity
Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype.Semantic proximity
Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and managementSemantic proximity
Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy.Semantic proximity
Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.Semantic proximity
Select a neighboring publication to make it the new centre.