Article
Period3 structural variation: a circadian biomarker associated with breast cancer in young women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2005
Zhu Yong, Brown Heather N, Zhang Yawei, Stevens Richard G, Zheng Tongzhang
Abstract excerpt
Circadian disruption has been indicated as a risk factor for breast cancer in recent epidemiologic studies. A novel finding in circadian biology is that genes responsible for circadian rhythm also regulate many other biological pathways, including cell proliferation, cell cycle regulation, and apoptosis. Therefore, mutations in circadian genes could conceivably result in deregulation of these processes and...
Topics
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
- Case-Control Studies
- Circadian Rhythm
- Female
- Genetic Variation
- Genotype
- Humans