Article
Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation.
Oncology reports - 1 Feb 2015
Alexander Melannie, Burch James B, Steck Susan E, Chen Chin-Fu, Hurley Thomas G, Cavicchia Philip, Ray Meredith, Shivappa Nitin, Guess Jaclyn, Zhang Hongmei, Youngstedt Shawn D, Creek Kim E, Lloyd Stephen, Yang Xiaoming, Hébert James R
Abstract excerpt
Clock genes are expressed in a self-perpetuating, circadian pattern in virtually every tissue including the human gastrointestinal tract. They coordinate cellular processes critical for tumor development, including cell proliferation, DNA damage response and apoptosis. Circadian rhythm disturbances have been associated with an increased risk for colon cancer and other cancers. This mechanism has not been...
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