Article
The role of polymorphisms in circadian pathway genes in breast tumorigenesis.
Breast cancer research and treatment - 1 Jun 2011
Dai Hongji, Zhang Lina, Cao Mingli, Song Fengju, Zheng Hong, Zhu Xiaoling, Wei Qingyi, Zhang Wei, Chen Kexin
Abstract excerpt
Disruption of the circadian rhythm or biological clock, which is regulated by a number of clock genes, including circadian locomotor output cycles kaput (CLOCK), period genes (PERs), and cryptochrome genes (CRYs), is a risk factor for breast cancer. We hypothesized that genetic variation in these clock genes may influence breast cancer risk. To test this hypothesis, we designed a hospital-based study that...
Topics
- Adult
- Aged
- Alleles
- Breast Neoplasms
- CLOCK Proteins
- Case-Control Studies
- Circadian Clocks
- Cryptochromes
- Female
- Genetic Predisposition to Disease
- Genotype