Article
Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2010
Climent Joan, Perez-Losada Jesus, Quigley David A, Kim Il-Jin, Delrosario Reyno, Jen Kuang-Yu, Bosch Ana, Lluch Ana, Mao Jian-Hua, Balmain Allan
Abstract excerpt
PURPOSE: To investigate the role of the PER3 circadian rhythm gene, located within the commonly deleted region of chromosome 1p36, in human breast cancer development. PATIENTS AND METHODS: The frequency of genetic alterations at 1p36 and PER3 gene copy number status were analyzed in 180 lymph node-negative breast cancers from patients who had received treatment with chemotherapy and/or tamoxifen. The expression...
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