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Article

Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk.

Breast cancer research and treatment - 1 Feb 2008

Zhu Yong, Stevens Richard G, Leaderer Derek, Hoffman Aaron, Holford Theodore, Zhang Yawei, Brown Heather N, Zheng Tongzhang

Abstract excerpt

Three known non-synonymous polymorphisms (Ala394Thr, Ser471Leu and Pro690Ala) in the largest circadian gene, Neuronal PAS domain protein 2 (NPAS2), were genotyped in a breast cancer case-control study conducted in Connecticut, USA (431 cases and 476 controls). We found that women with the heterozygous Ala394Thr genotype were significantly associated with breast cancer risk compared to those with the common...

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Source

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Identifiers

PMID: 17453337
DOI: 10.1007/s10549-007-9565-0
PMCID: PMC2366999

Genes

NPAS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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