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Article

Phenotyping of PER3 variants reveals widespread effects on circadian preference, sleep regulation, and health.

Sleep medicine reviews - 1 Aug 2018

Archer Simon N, Schmidt Christina, Vandewalle Gilles, Dijk Derk-Jan

Abstract excerpt

Period3 (Per3) is one of the most robustly rhythmic genes in humans and animals. It plays a significant role in temporal organisation in peripheral tissues. The effects of PER3 variants on many phenotypes have been investigated in targeted and genome-wide studies. PER3 variants, especially the human variable number tandem repeat (VNTR), associate with diurnal preference, mental disorders, non-visual responses to...

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Identifiers

PMID: 29248294
DOI: 10.1016/j.smrv.2017.10.008

Genes

PER3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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