Article
CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analyses.
Cancer research - 15 Feb 2010
Hoffman Aaron E, Yi Chun-Hui, Zheng Tongzhang, Stevens Richard G, Leaderer Derek, Zhang Yawei, Holford Theodore R, Hansen Johnni, Paulson Jennifer, Zhu Yong
Abstract excerpt
The transcription factors responsible for maintaining circadian rhythm influence a variety of biological processes. Recently, it has been suggested that the core circadian genes may play a role in breast tumorigenesis, possibly by influencing hormone regulation or other pathways relevant to cancer. To evaluate this hypothesis, we conducted a genetic and epigenetic association study, as well as a transcriptional...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
- CLOCK Proteins
- Case-Control Studies
- Epigenesis, Genetic
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic