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Article

CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analyses.

Cancer research - 15 Feb 2010

Hoffman Aaron E, Yi Chun-Hui, Zheng Tongzhang, Stevens Richard G, Leaderer Derek, Zhang Yawei, Holford Theodore R, Hansen Johnni, Paulson Jennifer, Zhu Yong

Abstract excerpt

The transcription factors responsible for maintaining circadian rhythm influence a variety of biological processes. Recently, it has been suggested that the core circadian genes may play a role in breast tumorigenesis, possibly by influencing hormone regulation or other pathways relevant to cancer. To evaluate this hypothesis, we conducted a genetic and epigenetic association study, as well as a transcriptional...

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Identifiers

PMID: 20124474
DOI: 10.1158/0008-5472.CAN-09-3798
PMCID: PMC3188957

Genes

CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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