Article
The HLA locus and multiple sclerosis in Sicily.
Neurology - 25 Jan 2005
Brassat D, Salemi G, Barcellos L F, McNeill G, Proia P, Hauser S L, Oksenberg J R, Savettieri G
Abstract excerpt
The authors report the analysis of HLA-class II allelic heterogeneity in a well characterized multiple sclerosis (MS) Sicilian dataset. Family-based association analysis revealed evidence for excess transmission to affected individuals for alleles HLA-DRB1*1501, DRB1*04, and DQB1*0302. When analyzed as haplotypes, the authors observed excess transmission for the DRB1*0400-DQB1*0302 haplotype. Sicilian patients...
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