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Article

HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia.

PloS one - 1 Jan 2012

Cocco Eleonora, Sardu Claudia, Pieroni Enrico, Valentini Maria, Murru Raffaele, Costa Gianna, Tranquilli Stefania, Frau Jessica, Coghe Giancarlo, Carboni Nicola, Floris Matteo, Contu Paolo, Marrosu Maria Giovanna

Abstract excerpt

INTRODUCTION: Genetic predisposition to multiple sclerosis (MS) in Sardinia (Italy) has been associated with five DRB1*-DQB1* haplotypes of the human leukocyte antigen (HLA). Given the complexity of these associations, an in-depth re-analysis was performed with the specific aims of confirming the haplotype associations; establishing the independence of the associated haplotypes; and assessing patients' genotypic...

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Identifiers

PMID: 22509268
DOI: 10.1371/journal.pone.0033972
PMCID: PMC3324467

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Source receipt: pubmed, retrieved 7 Sept 2026.

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