Article
HLA-DRB1 and multiple sclerosis in Malta.
Neurology - 8 Jan 2008
Dean G, Yeo T W, Goris A, Taylor C J, Goodman R S, Elian M, Galea-Debono A, Aquilina A, Felice A, Vella M, Sawcer S, Compston D A S
Abstract excerpt
BACKGROUND: By comparison with the neighboring island of Sicily, the frequency of multiple sclerosis (MS) in Malta is remarkably low. METHODS: To explore whether the relative rarity of MS in Malta might be the result of lower population frequencies of major histocompatibility complex susceptibility alleles, we genotyped the HLA-DRB1 locus in 77 Maltese-born patients (97% of the prevalent unrelated native cases)...
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