Article
HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain).
Journal of neurology - 1 Dec 2009
Fernández Oscar, R-Antigüedad Alfredo, Pinto-Medel María Jesús, Mendibe Mari Mar, Acosta Nestor, Oliver Begoña, Guerrero Miguel, Papais-Alvarenga Marcos, Fernández-Sánchez Victoria, Leyva Laura
Abstract excerpt
Genetic susceptibility to multiple sclerosis (MS) is associated with genes of the major histocompatibility complex, particularly with the HLA DRB1*1501-DQA1*0102-DQB1*0602 haplotype in Caucasians. To investigate the association of DRB1, DQA1 and DQB1 alleles and haplotypes with MS in Biscay, Basque Country, northern Spain, we examined 197 patients and 200 regionally matched controls. High resolution HLA class II...
Topics
- Adult
- Aged
- Alleles
- Female
- Genetic Predisposition to Disease
- HLA-D Antigens
- Histocompatibility Antigens Class II
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
- Spain
- White People