Article
Characterization of a small molecule PAI-1 inhibitor, ZK4044.
Thrombosis research - 1 Jan 2005
Liang Amy, Wu Faye, Tran Kathy, Jones Steven W, Deng Gary, Ye Bin, Zhao Zhuchun, Snider R Michael, Dole William P, Morser John, Wu Qingyu
Abstract excerpt
Plasminogen activator inhibitor-1 (PAI-1) is a key negative regulator of the fibrinolytic system. In animal studies, inhibition of PAI-1 activity prevents arterial and venous thrombosis, indicating that PAI-1 inhibitors may be used as a new class of antithrombotics. In this study, we characterize a small molecule PAI-1 inhibitor, ZK4044, which was identified by high throughput screening and chemically optimized....
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