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Article

Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1.

The Journal of biological chemistry - 4 Mar 2011

Lin Zhonghui, Jiang Longguang, Yuan Cai, Jensen Jan K, Zhang Xu, Luo Zhipu, Furie Barbara C, Furie Bruce, Andreasen Peter A, Huang Mingdong

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1), together with its physiological target urokinase-type plasminogen activator (uPA), plays a pivotal role in fibrinolysis, cell migration, and tissue remodeling and is currently recognized as being among the most extensively validated biological prognostic factors in several cancer types. PAI-1 specifically and rapidly inhibits uPA and tissue-type PA (tPA). Despite...

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Source

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Identifiers

PMID: 21199867
DOI: 10.1074/jbc.M110.204537
PMCID: PMC3044959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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