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Article

Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure.

International journal of molecular medicine - 1 Jan 2012

Jankun Jerzy, Yang Jie, Zheng Hong, Han Frank Q, Al-Senaidy Abdulrahman, Skrzypczak-Jankun Ewa

Abstract excerpt

Plasminogen activator inhibitor type 1 (PAI-1) is a serpin protein, a natural inhibitor of urokinase (uPA) and tissue plasminogen activators (tPA). By inhibiting uPA it can block growth of the cancer tumors by suppressing angiogenesis, while when acting on tPA in the blood it can avert conversion of plasminogen to plasmin preventing lysis of the clot. Furthermore, blocking PAI-1 activity can protect against...

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Identifiers

PMID: 21947232
DOI: 10.3892/ijmm.2011.798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure.PMID 21947232Read ↗

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