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Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484

2 Feb 2021

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, is the main physiological inhibitor of plasminogen activators. By interacting with matrix components, including vitronectin (Vn), PAI-1 plays a regulatory role in tissue remodeling, cell migration, and intracellular signaling. Emerging evidence points to a role for PAI-1 in various pathological conditions, including...

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PMID: 33540702
DOI: 10.3390/ijms22031482

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Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484PMID 33540702Read ↗

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