Characterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations

doi:10.1093/jac/dkh528

Article

Characterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations

22 Jan 2005

Abstract excerpt

OBJECTIVES AND METHODS: An influenza B virus plasmid-based rescue system was used to introduce site-specific mutations, previously observed in neuraminidase (NA) inhibitor-resistant viruses, into the NA protein of six recombinant viruses. Three mutations observed only among in vitro selected zanamivir-resistant influenza A mutants were introduced into the B/Beijing/1/87 virus NA protein, to change residue E116 to...

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