Article
Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors.
Virus research - 1 Jul 2004
Gubareva Larisa V
Abstract excerpt
A wide use of inhibitors of influenza virus neuraminidase (NAIs) to control influenza in humans demands a better understanding of the mechanisms involved in the resistance emergence. In vitro studies demonstrate that both neuraminidase (NA) and hemagglutinin (HA) influence virus susceptibility to NAIs. Drug resistance conferred due to changes in the NA could be monitored in the NA inhibition assays....
Topics
- Antiviral Agents
- Cell Line
- Drug Resistance, Viral
- Enzyme Inhibitors
- Humans
- Immunocompromised Host
- Influenza A virus
- Influenza B virus
- Influenza, Human
- Mutation
- Neuraminidase