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Article

In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses.

Antimicrobial agents and chemotherapy - 1 Oct 2009

Hurt Aeron C, Holien Jessica K, Barr Ian G

Abstract excerpt

To identify mutations that can arise in highly pathogenic A(H5N1) viruses under neuraminidase inhibitor selective pressure, two antigenically different strains were serially passaged with increasing levels of either oseltamivir or zanamivir. Under oseltamivir pressure, both A(H5N1) viruses developed a H274Y neuraminidase mutation, although in one strain the mutation occurred in combination with an I222M...

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Source

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Identifiers

PMID: 19651908
DOI: 10.1128/AAC.00334-09
PMCID: PMC2764219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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