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Article

I223R mutation in influenza A(H1N1)pdm09 neuraminidase confers reduced susceptibility to oseltamivir and zanamivir and enhanced resistance with H275Y.

PloS one - 1 Jan 2012

LeGoff Jérome, Rousset Dominique, Abou-Jaoudé Georges, Scemla Anne, Ribaud Patricia, Mercier-Delarue Séverine, Caro Valérie, Enouf Vincent, Simon François, Molina Jean-Michel, van der Werf Sylvie

Abstract excerpt

BACKGROUND: Resistance of pandemic A(H1N1)2009 (H1N1pdm09) virus to neuraminidase inhibitors (NAIs) has remained limited. A new mutation I223R in the neuraminidase (NA) of H1N1pdm09 virus has been reported along with H275Y in immunocompromised patients. The aim of this study was to determine the impact of I223R on oseltamivir and zanamivir susceptibility. METHODS: The NA enzymatic characteristics and...

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Identifiers

PMID: 22936969
DOI: 10.1371/journal.pone.0037095
PMCID: PMC3427316

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