Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses.

doi:10.1128/JVI.00477-06

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Article

Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses.

Journal of virology - 1 Sept 2006

Yen Hui-Ling, Hoffmann Erich, Taylor Garry, Scholtissek Christoph, Monto Arnold S, Webster Robert G, Govorkova Elena A

Abstract excerpt

Neuraminidase inhibitors (NAIs) are antivirals designed to target conserved residues at the neuraminidase (NA) enzyme active site in influenza A and B viruses. The conserved residues that interact with NAIs are under selective pressure, but only a few have been linked to resistance. In the A/Wuhan/359/95 (H3N2) recombinant virus background, we characterized seven charged, conserved NA residues (R118, R371, E227,...

Topics

Animals
Antiviral Agents
Binding Sites
Cell Line
Drug Resistance, Viral
Humans
Influenza A Virus, H3N2 Subtype
Microbial Sensitivity Tests
Mutation
Neuraminidase
Recombination, Genetic
Viral Plaque Assay

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Identifiers

PMID: 16912325
DOI: 10.1128/JVI.00477-06
PMCID: PMC1563878

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