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Article

Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro.

The Journal of antimicrobial chemotherapy - 1 Oct 2006

Zürcher Thomas, Yates Phillip J, Daly Janet, Sahasrabudhe Anjali, Walters Matthew, Dash Laura, Tisdale Margaret, McKimm-Breschkin Jennifer L

Abstract excerpt

BACKGROUND: Viruses resistant to zanamivir have been generated in vitro, but no resistant virus has yet been isolated from a zanamivir-treated immunocompetent patient. In contrast most resistant viruses isolated from oseltamivir-treated patients correspond to those selected in vitro. However, despite mutations being in conserved residues in the neuraminidase (NA) they do not confer resistance in all NA subtypes....

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Identifiers

PMID: 16891631
DOI: 10.1093/jac/dkl321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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