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Article

Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2009

Rubtsova Kira, Scott-Browne James P, Crawford Frances, Dai Shaodong, Marrack Philippa, Kappler John W

Abstract excerpt

We have hypothesized that in the prenegative selection TCR repertoire, many somatically generated complementary-determining region (CDR) 3 loops combine with evolutionarily selected germline Valpha/Vbeta CDR1/CDR2 loops to create highly MHC/peptide cross-reactive T cells that are subsequently deleted by negative selection. Here, we present a mutational analysis of the Vbeta CDR3 of such a cross-reactive T-cell...

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Identifiers

PMID: 19416894
DOI: 10.1073/pnas.0902728106
PMCID: PMC2674405

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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