Article
Shape-specific nucleotide binding of single-stranded RNA by the GLD-1 STAR domain.
Journal of molecular biology - 11 Feb 2005
Lehmann-Blount Katrina A, Williamson James R
Abstract excerpt
Proteins containing the STAR RNA-binding domain fulfill vital roles in RNA biogenesis, yet a detailed understanding of STAR domain RNA binding specificity is lacking. In Caenorhabditis elegans, the STAR protein GLD-1 directly binds the 28 nucleotide recognition element TGE within the 3' untranslated region of tra-2 mRNA. The GLD-1:TGE interaction promotes translational silencing of tra-2 mRNA, marking a pivotal...
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