Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.

Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 2011

Jenkins Huw T, Malkova Bara, Edwards Thomas A

Abstract excerpt

A defect in germ-cell (sperm and oocyte) development is the leading cause of male and female infertility. Control of translation through the binding of deleted in azoospermia (DAZ)-like (DAZL) to the 3'-UTRs of mRNAs, via a highly conserved RNA recognition motif (RRM), has been shown to be essential in germ-cell development. Crystal structures of the RRM from murine DAZL (Dazl), both alone and in complex with RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Models, Molecular

Share to Protein Binding

Share to RNA-Binding Proteins

Share to RNA, Messenger

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 22021443
DOI: 10.1073/pnas.1105211108
PMCID: PMC3215079

Genes

DAZL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.PMID 22021443Read ↗

Infertility-associated DAZL mutations and their effects on DAZL functionsSemantic proximity Read ↗

Identification of Target Messenger RNA Substrates for the Murine Deleted in Azoospermia-Like RNA-Binding Protein1Semantic proximity Read ↗

Identification of Two Novel Proteins That Interact with Germ-Cell-Specific RNA-Binding Proteins DAZ and DAZL1Semantic proximity Read ↗

Putative biological functions of the DAZ family.Semantic proximity Read ↗

The solution structure of Dead End bound to AU-rich RNA reveals an unprecedented mode of tandem RRM-RNA recognition required for mRNA regulationSemantic proximity Read ↗

Shape-specific nucleotide binding of single-stranded RNA by the GLD-1 STAR domain.Semantic proximity Read ↗

DAZ Family Proteins, Key Players for Germ Cell DevelopmentSemantic proximity Read ↗

The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturationSemantic proximity Read ↗

MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin TSemantic proximity Read ↗

Association of the Mouse Infertility Factor DAZL1 with Actively Translating Polyribosomes1Semantic proximity Read ↗

RNA recognition by a Staufen double-stranded RNA-binding domain.Semantic proximity Read ↗

A <i>Xenopus DAZ</i>-like gene encodes an RNA component of germ plasm and is a functional homologue of <i>Drosophila boule</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.