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Article

RNA recognition by a Staufen double-stranded RNA-binding domain.

The EMBO journal - 1 Mar 2000

Ramos A, Grünert S, Adams J, Micklem D R, Proctor M R, Freund S, Bycroft M, St Johnston D, Varani G

Abstract excerpt

The double-stranded RNA-binding domain (dsRBD) is a common RNA-binding motif found in many proteins involved in RNA maturation and localization. To determine how this domain recognizes RNA, we have studied the third dsRBD from Drosophila Staufen. The domain binds optimally to RNA stem-loops containing 12 uninterrupted base pairs, and we have identified the amino acids required for this interaction. By mutating...

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Identifiers

PMID: 10698941
DOI: 10.1093/emboj/19.5.997
PMCID: PMC305639

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