Article

Comparison of TRIBE and STAMP for identifying targets of RNA binding proteins in human and <i>Drosophila</i> cells

2023-02-04

Abstract excerpt

<h4>ABSTRACT</h4> RNA binding proteins (RBPs) perform a myriad of functions and are implicated in numerous neurological diseases. To identify the targets of RBPs in small numbers of cells, we developed TRIBE, in which the catalytic domain of the RNA editing enzyme ADAR (ADARcd) is fused to a RBP. When the RBP binds to a mRNA, ADAR catalyzes A to G modifications in the target mRNA that can be easily identified in...

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Literature Corpus work: 373a1db6-fb36-519e-984d-5199566f0f40
DOI: 10.1101/2023.02.03.527025

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