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Article

Structural and biochemical characterization of Schlafen11 N-terminal domain.

Nucleic acids research - 21 Jul 2023

Hou Pengjiao, Hao Wei, Qin Bo, Li Mengyun, Zhao Rong, Cui Sheng

Abstract excerpt

Schlafen11 (SLFN11) is one of the most studied Schlafen proteins that plays vital roles in cancer therapy and virus-host interactions. Herein, we determined the crystal structure of the Sus scrofa SLFN11 N-terminal domain (NTD) to 2.69 Å resolution. sSLFN11-NTD is a pincer-shaped molecule that shares an overall fold with other SLFN-NTDs but exhibits distinct biochemical characteristics. sSLFN11-NTD is a potent...

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Identifiers

PMID: 37293979
DOI: 10.1093/nar/gkad509
PMCID: PMC10359600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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