Article
Structural and functional implications of the QUA2 domain on RNA recognition by GLD-1.
Nucleic acids research - 1 Jul 2014
Daubner Gerrit M, Brümmer Anneke, Tocchini Cristina, Gerhardy Stefan, Ciosk Rafal, Zavolan Mihaela, Allain Frédéric H-T
Abstract excerpt
The STAR family comprises ribonucleic acid (RNA)-binding proteins that play key roles in RNA-regulatory processes. RNA recognition is achieved by a KH domain with an additional α-helix (QUA2) that seems to extend the RNA-binding surface to six nucleotides for SF1 (Homo sapiens) and seven nucleotides for GLD-1 (Caenorhabditis elegans). To understand the structural basis of this probable difference in specificity,...
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