Article
Somatic sex determination in Caenorhabditis elegans is modulated by SUP-26 repression of tra-2 translation.
Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2010
Mapes James, Chen Jeng-Ting, Yu Jau-Song, Xue Ding
Abstract excerpt
Translational repression mediated by RNA-binding proteins or micro RNAs has emerged as a major regulatory mechanism for fine-tuning important biological processes. In Caenorhabditis elegans, translational repression of the key sex-determination gene tra-2 (tra, transformer) is controlled by a 28-nucleotide repeat element, the TRA-2/GLI element (TGE), located in its 3' untranslated region (UTR). Mutations that...
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