Article
Variations in the hypervariable region 1 of the envelope region E2 of hepatitis C virus RNA appear associated with virus persistence independently of liver disease.
The Italian journal of gastroenterology - 1 Dec 1996
Brunetto M R, Suzuki T, Aizaky H, Flichman D, Colombatto P, Abate M L, Oliveri F, Matsuura Y, Bonino F, Miyamura T
Abstract excerpt
The high genetic variability of the 5' end of the envelope protein-coding region E2 (HVR1 E2) of Hepatitis C Virus (HCV) RNA has been suggested by many authors to play an important role in both virus persistence and outcome of liver disease. We studied the relations between HVR1 E2 variability and HCV genotypes, HCV-RNA levels and liver disease in 8 chronic HCV carriers (5 males and 3 females, median age 41...
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