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Article

Characterization of hypervariable regions in the putative envelope protein of hepatitis C virus.

Biochemical and biophysical research communications - 30 Nov 1992

Kato N, Ootsuyama Y, Ohkoshi S, Nakazawa T, Sekiya H, Hijikata M, Shimotohno K

Abstract excerpt

We previously identified two hypervariable regions [HVR1 (27 amino acids) and HVR2 (7 amino acids)] in the putative envelope glycoprotein (gp70) by comparison of the amino acid sequences of many isolates of the HCV-II genotype. To understand the functional features of these HVRs, using the polymerase chain reaction we analyzed the rate of actual sequence variability in the region including HVR1 and HVR2 of HCV...

Topics

Alanine Transaminase
Amino Acid Sequence
Cloning, Molecular
Female
Genetic Variation
Genotype
Hepacivirus
Hepatitis C
Humans
Interferon-beta
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Polymerase Chain Reaction

RNA, Viral

Restriction Mapping

Viral Envelope Proteins

Source

Identifiers

PMID: 1333186
DOI: 10.1016/0006-291x(92)91533-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1333186-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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