Article
Complexity of the HVR-1 quasispecies and disease activity in patients with hepatitis C.
European journal of clinical investigation - 1 Jul 2007
Kumagai N, Kaneko F, Tsunematsu S, Tsuchimoto K, Tada S, Saito H, Hibi T
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV) easily undergoes genomic changes, especially in the hypervariable region (HVR) in the N-terminus of the E2/NS1 region. The quasispecies nature of HCV may have important biological implications in relation to viral persistence; however, the relationship between disease activity of chronic HCV infection and development of the genomic complexity have yielded conflicting results....
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