Article
Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
Science (New York, N.Y.) - 3 Apr 1992
Sidransky D, Tokino T, Hamilton S R, Kinzler K W, Levin B, Frost P, Vogelstein B
Abstract excerpt
Colorectal (CR) tumors are usually curable if detected before metastasis. Because genetic alterations are associated with the development of these tumors, mutant genes may be found in the stool of individuals with CR neoplasms. The stools of nine patients whose tumors contained mutations of K-ras were analyzed. In eight of the nine cases, the ras mutations were detectable in DNA purified from the stool. These...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.