Article
Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
Science (New York, N.Y.) - 3 Apr 1992
Sidransky D, Tokino T, Hamilton S R, Kinzler K W, Levin B, Frost P, Vogelstein B
Abstract excerpt
Colorectal (CR) tumors are usually curable if detected before metastasis. Because genetic alterations are associated with the development of these tumors, mutant genes may be found in the stool of individuals with CR neoplasms. The stools of nine patients whose tumors contained mutations of K-ras...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Base Sequence
- Blotting, Southern
- Carcinoma
- Colonic Neoplasms
- DNA, Neoplasm
- Feces
- Female
- Genes, ras
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction