Article
Detecting colorectal cancer in stool with the use of multiple genetic targets.
Journal of the National Cancer Institute - 6 Jun 2001
Dong S M, Traverso G, Johnson C, Geng L, Favis R, Boynton K, Hibi K, Goodman S N, D'Allessio M, Paty P, Hamilton S R, Sidransky D, Barany F, Levin B, Shuber A, Kinzler K W, Vogelstein B, Jen J
Abstract excerpt
BACKGROUND: Colorectal cancer cells are shed into the stool, providing a potential means for the early detection of the disease using noninvasive approaches. Our goal was to develop reliable, specific molecular genetic tests for the detection of colorectal cancer in stool samples. METHODS: Stool DNA was isolated from paired stools and primary tumor samples from 51 colorectal cancer patients. Three genetic...
Topics
- Aged
- Colonic Neoplasms
- Colorectal Neoplasms
- DNA
- Feces
- Genes, p53
- Genes, ras
- Genetic Markers
- Germ-Line Mutation
- Humans
- Middle Aged