Article
Stool DNA analysis detects premorphological colorectal neoplasia: a case report.
European journal of gastroenterology & hepatology - 1 Aug 2007
Øgreid Dagfinn, Hamre Erik
Abstract excerpt
We found, in an asymptomatic patient with familial occurrence of malignancy, that mutations in the oncogene Kras could be detected in stool 18 months before a premalignant polyp was detected and removed endoscopically. Colorectal cancers usually develop from benign adenomas in a lengthy period of 5-10 years. During this period, several major biochemical pathways are involved, each characterized by one or several...
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