Article
Detection of the mutated K-Ras biomarker in colorectal carcinoma.
Experimental and molecular pathology - 1 Jun 2001
Doolittle B R, Emanuel J, Tuttle C, Costa J
Abstract excerpt
This study describes an advantageous, effective protocol for detecting K-Ras mutations in human stool as a prototype screen for colorectal carcinoma (CRC), the third most common malignancy in the United States. A reliable screening test that detects early lesions would contribute to a decrease in...
Topics
- Biomarkers, Tumor
- Colorectal Neoplasms
- DNA
- DNA, Neoplasm
- Deoxyribonuclease EcoRI
- Feces
- Genes, ras
- Humans
- Indicators and Reagents
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Quaternary Ammonium Compounds
- Reference Values
- Reproducibility of Results
- Site-Specific DNA-Methyltransferase (Adenine-Specific)
- Trimethyl Ammonium Compounds