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Article

Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor.

Protein science : a publication of the Protein Society - 1 Feb 2005

Dattelbaum Jonathan D, Looger Loren L, Benson David E, Sali Kevin M, Thompson Richard B, Hellinga Homme W

Abstract excerpt

We previously reported the construction of a family of reagentless fluorescent biosensor proteins by the structure-based design of conjugation sites for a single, environmentally sensitive small molecule dye, thus providing a mechanism for the transduction of ligand-induced conformational changes into a macroscopic fluorescence observable. Here we investigate the microscopic mechanisms that may be responsible for...

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Share to Allosteric Site
Share to Biosensing Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histidine

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Share to Maltose-Binding Proteins

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Source

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Identifiers

PMID: 15659363
DOI: 10.1110/ps.041146005
PMCID: PMC2253422

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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