Article
The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997
Marvin J S, Corcoran E E, Hattangadi N A, Zhang J V, Gere S A, Hellinga H W
Abstract excerpt
Rational protein design is an emerging approach for testing general theories of structure and function. The ability to manipulate function rationally also offers the possibility of creating new proteins of biotechnological value. Here we use the design approach to test the current understanding o...
Topics
- ATP-Binding Cassette Transporters
- Allosteric Regulation
- Binding Sites
- Biosensing Techniques
- Biotechnology
- Carrier Proteins
- Computer Simulation
- Escherichia coli Proteins
- Fluorescent Dyes
- Maltose
- Maltose-Binding Proteins
- Models, Molecular
- Monosaccharide Transport Proteins
- Mutation