Article
The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997
Marvin J S, Corcoran E E, Hattangadi N A, Zhang J V, Gere S A, Hellinga H W
Abstract excerpt
Rational protein design is an emerging approach for testing general theories of structure and function. The ability to manipulate function rationally also offers the possibility of creating new proteins of biotechnological value. Here we use the design approach to test the current understanding of the structural principles of allosteric interactions in proteins and demonstrate how a simple allosteric system can...
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