Article
Manipulation of ligand binding affinity by exploitation of conformational coupling.
Nature structural biology - 1 Sept 2001
Marvin J S, Hellinga H W
Abstract excerpt
Traditional approaches for increasing the affinity of a protein for its ligand focus on constructing improved surface complementarity in the complex by altering the protein binding site to better fit the ligand. Here we present a novel strategy that leaves the binding site intact, while residues...
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