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Article

A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage.

Biochemical and biophysical research communications - 19 Jan 2007

Danoy Patrick, Sonoda Eiichiro, Lathrop Mark, Takeda Shunichi, Matsuda Fumihiko

Abstract excerpt

Homologous recombination, a major double strand break repair pathway, plays critical roles in maintaining genome stability. Genetic polymorphisms in HR genes have been implicated in cancer risk. We report a novel assay system for evaluating polymorphisms in human homologous recombination genes using a panel of chicken DT40 repair mutants. We established mutant cell lines complemented with either wild-type or...

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Source

Identifiers

PMID: 17141189
DOI: 10.1016/j.bbrc.2006.11.083

Genes

XRCC2
RAD51
XRCC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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