Article
Matrix metalloproteinase gene polymorphisms and susceptibility to systemic sclerosis.
Genetics and molecular research : GMR - 19 Dec 2016
Rech T F, Moraes S B C, Bredemeier M, de Paoli J, Brenol J C T, Xavier R M, Chies J A B, Simon D
Abstract excerpt
The major pathological hallmark of the systemic sclerosis (SSc) is skin and internal organ fibrosis, which results from normal tissue architecture alterations and extracellular matrix (ECM) protein deposition. ECM components are degraded by matrix metalloproteinases (MMP). Promoter region polymorphisms in MMP genes may influence gene expression, resulting in an imbalance between ECM protein production and...
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