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Article

A polymorphism in the CTGF promoter region associated with systemic sclerosis.

The New England journal of medicine - 20 Sept 2007

Fonseca Carmen, Lindahl Gisela E, Ponticos Markella, Sestini Piersante, Renzoni Elisabetta A, Holmes Alan M, Spagnolo Paolo, Pantelidis Panagiotis, Leoni Patricia, McHugh Neil, Stock Carmel J, Shi-Wen Xu, Denton Christopher P, Black Carol M, Welsh Kenneth I, du Bois Roland M, Abraham David J

Abstract excerpt

BACKGROUND: Systemic sclerosis (scleroderma) is a life-threatening autoimmune disease that is characterized by the presence of specific autoantibodies and fibrosis of the skin and major internal organs. METHODS: We genotyped a polymorphism (G-945C) in the promoter of the connective-tissue growth factor (CTGF) gene in 1000 subjects in two groups: group 1, consisting of 200 patients with systemic sclerosis and 188...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

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Share to Sequence Analysis, DNA

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Source

Identifiers

PMID: 17881752
DOI: 10.1056/NEJMoa067655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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