Association of a functional polymorphism in the matrix metalloproteinase-12 promoter region with systemic sclerosis in an Italian population.

doi:10.3899/jrheum.100237

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Article

Association of a functional polymorphism in the matrix metalloproteinase-12 promoter region with systemic sclerosis in an Italian population.

The Journal of rheumatology - 1 Sept 2010

Manetti Mirko, Ibba-Manneschi Lidia, Fatini Cinzia, Guiducci Serena, Cuomo Giovanna, Bonino Claudia, Bazzichi Laura, Liakouli Vasiliki, Giacomelli Roberto, Abbate Rosanna, Bombardieri Stefano, Montecucco Carlomaurizio, Valentini Gabriele, Matucci-Cerinic Marco

Abstract excerpt

OBJECTIVE: To investigate the possible implication of the matrix metalloproteinase-12 (MMP-12) gene in the genetic predisposition to systemic sclerosis (SSc) susceptibility and clinical phenotype. METHODS: The MMP-12 rs2276109 A/G functional polymorphism was selected as a genetic marker and genot...

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PMID: 20595276
DOI: 10.3899/jrheum.100237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20595276-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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