An MIF Promoter Polymorphism Is Associated with Susceptibility to Pulmonary Arterial Hypertension in Diffuse Cutaneous Systemic Sclerosis.

doi:10.3899/jrheum.161369

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Article

An MIF Promoter Polymorphism Is Associated with Susceptibility to Pulmonary Arterial Hypertension in Diffuse Cutaneous Systemic Sclerosis.

The Journal of rheumatology - 1 Oct 2017

Bossini-Castillo Lara, Campillo-Davó Diana, López-Isac Elena, Carmona Francisco David, Simeon Carmen P, Carreira Patricia, Callejas-Rubio José Luis, Castellví Iván, Fernández-Nebro Antonio, Rodríguez-Rodríguez Luis, Rubio-Rivas Manel, García-Hernández Francisco J, Madroñero Ana Belén, Beretta Lorenzo, Santaniello Alessandro, Lunardi Claudio, Airó Paolo, Hoffmann-Vold Anna-Maria, Kreuter Alexander, Riemekasten Gabriela, Witte Torsten, Hunzelmann Nicolas, Vonk Madelon C, Voskuyl Alexandre E, de Vries-Bouwstra J, Shiels Paul, Herrick Ariane, Worthington Jane, Radstake Timothy R D J, Martin Javier

Abstract excerpt

OBJECTIVE: Systemic sclerosis (SSc) is a fibrotic immune-mediated disease of unknown etiology. Among its clinical manifestations, pulmonary involvement is the leading cause of mortality in patients with SSc. However, the genetic factors involved in lung complication are not well defined. We aimed to review the association of the MIF gene, which encodes a cytokine implicated in idiopathic pulmonary hypertension...

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PMID: 28668810
DOI: 10.3899/jrheum.161369

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