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Article

Novel Roles of Unphosphorylated STAT3 in Oncogenesis and Transcriptional Regulation

1 Feb 2005

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is phosphorylated on tyrosine residue 705 in response to growth factors or cytokines to form activated homodimers that drive gene expression. Because the stat3 promoter has a binding site for STAT3 dimers, the amount of STAT3 protein increases when STAT3 is activated (e.g., in response to interleukin 6). Unphosphorylated STAT1 is known to drive the...

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PMID: 15705894
DOI: 10.1158/0008-5472.939.65.3

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