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The Roles of post-translational Modifications and Coactivators of STAT6 Signaling in Tumor Growth and Progression

11 Aug 2020

Abstract excerpt

Signal transducers and activators of transcription 6 (STAT6) are highly expressed in various tumors and associated with tumorigenesis, immunosuppression, proliferation, metastasis and poor prognosis in human cancers. In response to IL-4/13, STAT6 is phosphorylated, dimerizes and triggers transcriptional regulation after recruitment of coactivators to transcriptosome, such as CBP/p300, SRC-1, PARP-14 and PSF....

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PMID: 32779479
DOI: 10.4155/fmc-2020-0224

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