Article
Acetylation of Stat1 modulates NF-kappaB activity.
Genes & development - 15 Feb 2006
Krämer Oliver H, Baus Daniela, Knauer Shirley K, Stein Stefan, Jäger Elke, Stauber Roland H, Grez Manuel, Pfitzner Edith, Heinzel Thorsten
Abstract excerpt
Acetylation of signaling molecules can lead to apoptosis or differentiation of carcinoma cells. The molecular mechanisms underlying these processes and the biological role of enzymes mediating the transfer or removal of an acetyl-group are currently under intense investigation. Our study shows that Stat1 is an acetylated protein. Stat1 acetylation depends on the balance between Stat1-associated histone...
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